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Additionally, there have been no documented cases of dementia in nearly 30 years of follow-up for this cohort, nor any mention of dementia as a cause of death on the death certificates of IGHD subjects born since 1892 (133) (Figure 2)

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This is critical because droplet size determines where in the nasal cavity the drug deposits: droplets in the appropriate size range (typically 30–200 μm for nasal sprays) deposit in the nasal turbinates, where absorption occurs, while excessively small droplets may penetrate to the lower respiratory tract, and excessively large droplets may not clear the nasal vestibule